Evaluation of the Efficacy of a Reviving Cream on Skin Firmness, Wrinkles, and Barrier Function

Authors: Joyce Theisen, Patricia Schuffenhauer, and Marsha Tharakan DDS, MD

Abstract

Objective: To evaluate the effects of a reviving cream on skin firmness, elasticity, wrinkle reduction, and barrier repair function.

Methods: This open, intra-individual study involved 33 female subjects aged 20-60 years. Measurements were taken at baseline, day 14, and day 28 using Cutometer® for firmness/elasticity (face), PRIMOS-CR® 45 for wrinkle analysis (face), and Tewameter® for barrier function assessment (forearm). Barrier function was evaluated through tape stripping with treated and non-treated zones.

Results: After 28 days, statistically significant improvements were observed in skin firmness (F4: -11%, p<0.0001; R0: -6%, p=0.0124) and elasticity parameters (R2: +5%, p=0.0004; R5: +6%, p=0.0024; R7: +5%, p=0.0042). Wrinkle parameters showed statistically significant reductions (Pz: -6%, p=0.0277; Rz: -6%, p=0.0068; Rt: -8%, p=0.0010). For barrier function, the cream demonstrated statistically significant improvement in TEWL compared to non-treated zones at 2 hours (-14%, p<0.0001) and 8 hours (-16%, p<0.0001) after single application. After 7 days, treated zones showed statistically significantly better barrier recovery compared to non-treated zones (-19%, p<0.0001).

Conclusion: The reviving cream demonstrated significant efficacy in improving skin firmness and elasticity, reducing wrinkle parameters, and enhancing skin barrier function through both immediate and long-term recovery effects.

Keywords: skin firmness, wrinkles, barrier function, clinical study, cosmetic efficacy.

See Publication on American Academy of Dermatology Association: https://eposters.aad.org/abstracts/75454